報告題目🙇🏽:Modelling the treatment of melanoma with dendritic cell vaccines and immune checkpoint inhibitors
報告人:薛 玲 教授 (哈爾濱工程大學數學科學必一)
報告時間:2023年5月21日(星期日)上午10:00-11:00
報告地點:必一体育平台會議室(卓越樓810)
報告摘要:Dendritic cell (DC) vaccines and immune checkpoint inhibitors (ICIs) play critical roles in shaping the immune responses of tumor cells (TCs), and are widely used in cancer immunotherapies. Quantitatively evaluating the effectiveness of these therapies are essential for the optimization of treatment strategies. In this talk, I present the mathematical models developed to predict the responses of melanoma patients to immunotherapy. Multiple monotherapies and combined therapy with model simulations were tested. Our results indicated that DC vaccines can decelerate the growth of TCs, ICIs can inhibit the growth of TCs, both therapies can prolong the lifetime of patients, and the combined therapy of DC vaccines and ICIs can effectively eradicate TCs.
薛玲教授簡介: 教授、博士生導師🎢、生物數學團隊學科帶頭人🫵🏿、黑龍江省工業與應用數學會常務理事、黑龍江省工程與應用重點實驗室副主任、Applied Science and Technology 期刊的編委、Frontiers in Physics期刊的客座主編🙅♂️。2013年在美國堪薩斯州立大學獲得博士學位🏋🏿♀️,2014年至2016年,在美國杜蘭大學數學系與數學計算科學中心,從事博士後研究工作,合作導師是James. Mac Hyman教授;2016年至2017年,受到加拿大太平洋數學研究院和加拿大曼尼托巴大學數學系的聯合資助,在加拿大曼尼托巴大學數學系與Julien Arino以及Felicia Magpantay共同合作研究💺㊙️。在Journal of Differential Equation、SIAM J Appl Math、PloS Neglected Tropical Diseases、Bulletin of Mathematical Biology、Journal of Theoretical Biology🦴、Mathematical Biosciences等SCI 期刊發表論文30余篇。