報告題目：Pharmacokinetic models with simultaneous elimination pathways and endogenous production
報告人：吳孝鈿副教授（上海海事大學）
報告時間🤾🏻🫅🏼：2019年1月11日（星期五）下午4:30-5:30
報告地點：必一体育平台二樓會議室
報告摘要：Biological agents, such as therapeutic monoclonal antibodies (mAbs) and growth factors, are widely used for chemotherapy or other diseases. Additional to a linear elimination (typical liver or kidneys), these drugs generally should pass a process of internalization/metabolism, which often show significant nonlinear elimination properties. Meanwhile, apart from the exogenous drug administrations, they can generally be endogenously produced. Through mathematical studying of pharmacokinetic models, I will present the pharmacological characterization for such drugs such as rational estimation of drug exposure, principle of dose frequency and so on. Our findings definitely shed light on the fundamental knowledge in pharmacometrics, update the traditional rules that used in clinical practice, and offer some valuable information to support the decision making at all stages of drug development.
報告人簡介：吳孝鈿，加拿大約克大學應用數學博士🤷🏿，加拿大西安大略大學應用數學系和蒙特利爾大學藥學系博士後。主要從事經蟲媒傳播的傳染病的數學建模以及藥理學中的藥物動力學的數學分析和數值仿真。在《Journal of Theoretical Biology》、《Bulletin of Mathematical Biology》、《Environmental Health Perspectives》🌛、《Journal of Pharmacokinetocs and Pharmacodynamics》以及《Journal of Mathematical Biology》等國際著名期刊發表SCI期刊論文近20篇。現主持國家青年基金一項（NSFC）以及海外加拿大魁北克省博士後基金項目（FRQNT），並參與國內及海外加拿大項目。